Modeling the Recovery of Diclofenac and Indomethacin Using Molecularly Imprinted Polymers
Abstract
The recovery of pharmaceutical contaminants from environmental matrices has become a critical concern due to their potential impacts on ecosystems and human health. This study focuses on the modeling and optimization of the recovery process for two widely used nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac and indomethacin, utilizing molecularly imprinted polymers (MIPs) as selective adsorbents. MIPs are designed to selectively bind target molecules through specific molecular recognition sites formed during the polymerization process. This research aims to develop and refine models for the effective recovery of diclofenac and indomethacin from complex mixtures, providing insights into the efficiency and practicality of MIPs in environmental remediation.
The primary objective of this study was to model the recovery of diclofenac and indomethacin using MIPs and to evaluate the performance of these polymers in selective adsorption and subsequent desorption of the target pharmaceuticals. The research involved the synthesis of MIPs tailored for diclofenac and indomethacin, followed by the development of computational and empirical models to understand and predict their recovery efficiencies.
Keywords
Diclofenac, Indomethacin, Molecularly Imprinted Polymers, Drug Recovery, Analytical ModelingHow to Cite
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